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DNA Collection

DNA Collection Model Demonstration Model

Teaching Points

The information that determines an organism's specific features is encoded within the genetic sequence of deoxyribonucleic acid (DNA). The structure of DNA is a double helix with two anti-parallel strands of nucleotides joined by phosphodiester bonds. The two strands align with a base on one strand complementing the base on the opposite strand. These complementary base pairs are connected through hydrogen bonds to stabilize the structure.

With this model collection students can:

  • assemble nucleotides from sugar, phosphate and nitrogenous bases
  • assemble a segment of DNA using the nucleotide units
  • compare the minor and major grooves in the B–form of DNA
  • explore the interaction of DNA with histones in a nucleosome
  • examine the phosphodiester bonds between nucleotides
  • observe a benzpyrene ring, the major carcinogen in cigarette smoke, intercalated within the double helix

Models in this Collection

  • B–form DNA
  • Single stranded DNA
  • DNA with benzpyrene adduct
    • 11 base pairs of B–DNA with benzpyrene intercalated between bases
  • Nucleosome
    • Nucleosome core particle containing 8 histone proteins and 146 base pairs of DNA
    • DNA in backbone format and colored white with base pairs represented by struts connecting the phosphates of opposite strands
  • 4 base pairs from the DNA Discovery Kit
    • 2 each of adenosine, thymine, guanine and cytosine nucleotides (with labels)
    • Each nucleotide has magnets for joining 3'OH to adjacent nucleotide at 5' phosphate; magnets also demonstrate hydrogen bonding between base pairs
    • Nucleotides can be dismantled to show phosphate group, deoxyribose, and nitrogenous base.

 

Requesting this Model

Loan Time Frame: 3 weeks

Delivery

  • Use the calendar below to select a three week loan. Available times are shown in green. Select a date one week prior to the date you want the model to arrive. After selecting your time period, select checkout and complete the booking details.
  • This loan includes both delivery and return shipping time. Please make sure to plan time (approximately one week) for us to deliver the model to you. You can expect the model to arrive approximately one week following the first day of the requested loan period.

Pick-Up

  • Use the calendar below to select a three week loan. Available times are shown in green. Select the date you want to pick-up the model. After selecting your time period, select checkout and complete the booking details.

Requesting Other Models

You may schedule one copy of a model for three weeks. Due to limited resources, we are unable to send multiple copies or additional materials.

If you would like to request a loan of a different model for the same time frame you may add this to your cart. Up to three different types of models may be checked out at one time. You will need to fill out a separate request for model loans with a different time frame.

Questions?

Please contact us at cbmloans@msoe.edu with any questions about the lending process or the availability of models.

Contact Margaret Franzen at franzen@msoe.edu or (414) 277-2824 with questions about the models, teaching resources or educational content.

 

Model Documentation and Instructions

Teaching Points and Inventory

Returning Models

Models must be returned on or before the due date. Borrowers are responsible for return shipping costs.

Ship models to:
Receiving
Milwaukee School of Engineering
1000 N. Market Street
Milwaukee, WI 53202-3113

Please insure the models for the amount indicated in each suitcase. Any damage incurred in return shipping due to improper packing will be charged to the borrower. We recommend using FedEx or UPS with "two-day ground" transportation. Make sure to get a tracking number for the shipment.


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